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To identify robust and reproducible factors associated with suicidal thoughts and behaviors (STBs) in college students. 356 first-year university students completed a large battery of demographic and clinically-relevant self-report measures during the first semester of college and end-of-year ( n  = 228). Suicide Behaviors Questionnaire-Revised (SBQ-R) assessed STBs. A machine learning (ML) pipeline using stacking and nested cross-validation examined correlates of SBQ-R scores. 9.6% of students were identified at significant STBs risk by the SBQ-R. The ML algorithm explained 28.3% of variance (95%CI: 28–28.5%) in baseline SBQ-R scores, with depression severity, social isolation, meaning and purpose in life, and positive affect among the most important factors. There was a significant reduction in STBs at end-of-year with only 1.8% of students identified at significant risk. Analyses replicated known factors associated with STBs during the first semester of college and identified novel, potentially modifiable factors including positive affect and social connectedness.

A machine learning analysis of risk and protective factors of suicidal thoughts and behaviors in college students