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DNA methylation in the CpG sites of intron 1 of  HIF3A  is associated with body mass index (BMI). This cross-sectional study investigated correlations between DNA methylation of  HIF3A  and BMI or adiposity parameters in the Japanese population. DNA methylation of  HIF3A  was quantified via pyrosequencing. DNA methylation of  HIF3A  differed only in women; DNA methylation level at cg27146050 was associated with visceral adipose tissue thickness and correlated with BMI and percent (%) body fat after excluding smokers. Peripheral blood DNA methylation at the CpG site (cg27146050) of  HIF3A  correlated with VAT thickness in Japanese women.

endocrine research

Association between the Extent of Peripheral Blood DNA Methylation of  HIF3A  and Accumulation of Adiposity in community-dwelling Women: The Yakumo Study