English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The main objective of the present study is to isolate and characterise the novel bioactive molecule, 2-methoxy mucic acid  (4)  from  Rhizophora apiculate  Blume under the  Rhizophoraceae  family. In this study, the 2-methoxy mucic acid ( 4)  was isolated for the first time from the methanolic extract of the leaves of  R. apiculata . Anticancer activity of 2-methoxy mucic acid ( 4 ) was evaluated against HeLa and MDA-MB-231 cancer cell lines and they displayed promising activity with IC 50  values of 22.88283 ± 0.72 µg/ml in HeLa and 2.91925 ± 0.52 µg/ml in the case of MDA-MB-231, respectively. Furthermore, the antioxidant property of 2-methoxy mucic acid ( 4 ) was found to be (IC 50 ) 21.361 ± 0.41 µg/ml. Apart from  in vitro  studies, we also performed extensive  in silico  studies (molecular docking and molecular dynamics simulation) on four critical antiapoptotic Bcl-2 family members (Bcl-2, Bcl-w, Bcl-xL and Bcl-B) towards 2-methoxy mucic acid ( 4) . The results revealed that this molecule showed higher binding affinity towards Bcl-B protein ( ΔG  = −5.8 kcal/mol) and the structural stability of this protein was significantly improved upon binding of this molecule. The present study affords vital insights into the importance of 2-methoxy mucic acid ( 4 ) from  R. apiculata . Furthermore, it opens the therapeutic route for the discovery of anticancer drugs.Research HighlightsThis is a first report on a bioactive compound identified and characterised; a novel 2-methoxy mucic acid derived from methanolic crude extract from the leaves of  R. apiculata  from ANI.Estimated binding free energy of 2-methoxy mucic acid is found to be −5.8 kcal/mol to the anti-apoptotic Bcl-B protein.2-methoxy mucic acid showed both significant anti-cancer and anti-oxidant activity. This is a first report on a bioactive compound identified and characterised; a novel 2-methoxy mucic acid derived from methanolic crude extract from the leaves of  R. apiculata  from ANI. Estimated binding free energy of 2-methoxy mucic acid is found to be −5.8 kcal/mol to the anti-apoptotic Bcl-B protein. 2-methoxy mucic acid showed both significant anti-cancer and anti-oxidant activity. Communicated by Ramaswamy H. Sarma

journal of biomolecular structure and dynamics

Isolation, characterisation, anticancer and anti-oxidant activities of 2-methoxy mucic acid from  Rhizophora apiculata : an  in vitro  and  in silico  studies