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Inhibition of α-amylase enzyme is of key significance for the therapy of diabetes mellitus (DM). Numerous indole-based compounds have earlier been described for broad range of bioactivities. From our previous study, we knew that indole and thiadiazole are potent inhibitors of diabetics II. We design the hybrid molecules of them and synthesized 18 derivatives of indole-based-thiadiazole ( 1 – 18 ). All synthesized compounds were characterized using different spectroscopic methods and evaluated for their α-amylase inhibitory activities. All synthetic compounds, except  4 ,  13 ,  15  and  16 , were found to be strongly active (IC 50  values in the range of 0.80 ± 0.05 − 9.30 ± 0.20 µM) than the standard drug, acarbose (IC 50  = 11.70 ± 0.10 µM). Nevertheless, compound  18  was found to be inactive. The modes of binding interactions of five most active compounds  2 ,  3 ,  5 ,  10  and  17  were also studies through molecular docking study. In brief, current study identifies a novel class of α-amylase inhibitors which can be further studied for the treatment of hyperglycemia and obesity. Communicated by Ramaswamy H. Sarma

An effort to find new α - amylase inhibitors as potent antidiabetics compounds based on indole-based-thiadiazole analogs