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Hydroxychloroquine (HCQ) and its derivatives have recently gained tremendous attention as a probable medicinal agent in the COVID-19 outbreak caused by SARS-CoV-2. An efficient agent to act directly in inhibiting the SARS-CoV-2 replication is yet to be achieved. Thus, the goal is to investigate the dynamic nature of HCQ derivatives against SARS-CoV-2 main protease and spike proteins. Molecular docking studies were also performed to understand their binding affinity  in silico  methods using the vital protein domains and enzymes involved in replicating and multiplying SARS-CoV-2, which were the main protease and spike protein. Molecular Dynamic simulations integrated with MM-PBSA calculations have identified  In silico  potential inhibitors ZINC05135012 and ZINC59378113 against the main protease with −185.171 ± 16.388, −130.759 ± 15.741 kJ/mol respectively, ZINC16638693 and ZINC59378113 against spike protein −141.425 ± 22.447, −129.149 ± 11.449 kJ/mol. Identified Hit molecules had demonstrated Drug Likeliness features, PASS values and ADMET predictions with no violations. Communicated by Ramaswamy H. Sarma

Computational study for identifying promising therapeutic agents of hydroxychloroquine analogues against SARS‐CoV‐2