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Antibiotic resistance is a global concern. Two members of the bacterial genus  Elizabethkingia,  namely,  E. anophelis  and  E. meningoseptica  have raised much concern in recent years because of their resistance to multiple commonly used antibiotics. Identification of multidrug resistant and pan-drug resistant bacteria has propelled the search for new antibiotics that can act on unconventional targets. Researches are going on to find out the possibility of using bacterial ribonucleotide reductases as a novel target for antibiotic development. Through  in silico  evaluations, this study aims for characterization and functional annotation of ribonucleotide reductase enzymes of  E. anophelis  and  E. meningoseptica . Binding affinities with these enzymes of the compounds that have shown promising results in inhibiting  Pseudomonas aeruginosa  growth by acting on its ribonucleotide reductase were also assessed by molecular docking and dynamics simulations. Insights from this study will help in battling these infections in the near future. Communicated by Ramaswamy H. Sarma

journal of biomolecular structure and dynamics

Characterization of ribonucleotide reductases of emerging pathogens  Elizabethkingia anophelis  and  Elizabethkingia meningoseptica  and streptonigrin as their inhibitor: a computational study