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It is familiar that essential proteins take part in managing cellular activities in living organisms. Moreover, protein structure prediction from its amino acid sequence is advantageous to the comprehending of cellular functions. Formerly, several essential protein prediction methods have been proposed. However, those existing prediction methods were not satisfactory because to low sensitivity to imbalance characteristics. To address this issue, this paper presents a novel secondary protein structure prediction method, called, Bingham Deep Convolutional-based Oppositional Artificial Fish Optimized (BDC-OAFO). First, a protein structure identification framework, called, Bingham Distributed Deep Convolutional (BDDC) is designed to identify the essential proteins by eliminating the imbalanced learning issue. Next, secondary structure prediction framework, called, Oppositional Artificial Fish Swarm Optimization is proposed that obtain precise prediction results. Then, predicting secondary protein structure by emulating three biological behaviors of artificial fishes, including foraging behavior, following behavior, swarming behavior in which process, proximal count, oppositional function and Gaussian function are utilized. To evaluate the performance of BDC-OAFO method, we conduct experiments on Protein Data Bank dataset the experimental results show that our method BDC-OAFO achieves a better performance for identifying essential proteins and precise prediction in comparison with several other well-known prediction methods, which confirms the significance of BDC-OAFO. Communicated by Ramaswamy H. Sarma

Bingham deep neural and oppositional fish swarm optimized protein structure prediction