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Objective  Early childhood caries (ECC) is closely related to the disorders of oral microbiota. Probiotics antagonize pathogenic bacteria and regulate the composition of the microbiota. We aimed to investigate the effects of  Lactiplantibacillus plantarum  CCFM8724 on  Streptococcus mutans ,  Candida albicans , and oral microbiota of patients. Methods  Children with ECC aged 3‒6 years were randomly divided into probiotic and placebo groups in the double-blind controlled trial. The intervention and washout periods were 28 days and 14 days, respectively. On days 1 and 28, dental plaques were collected. The effects of  L. plantarum  CCFM8724 on the oral microbiota of patients were investigated by sequencing the V3-V4 region of 16S rDNA. On days 1, 14, 28 and 42, qPCR was used to investigate the effect of  L. plantarum  CCFM8724 on the amounts of  S. mutans  and  C. albicans  in the saliva of children with ECC. ResultsL. plantarum  CCFM8724 significantly reduced the amounts of  S. mutans  and  C. albicans  in saliva of children with ECC ( p  &lt; 0.01). After consumption of  L. plantarum  CCFM8724, the abundance of  Firmicutes ,  Granulicatella  and  Gemella  increased, whereas the abundance of  Proteobacteria ,  Neisseria ,  Bifidobacterium  and  Catonella  decreased. Conclusion: Our results emphasize that probiotics could play a beneficial role in the prevention and treatment of ECC in children from an oral microecological perspective.

journal of the american nutrition association

Lactiplantibacillus Plantarum  CCFM8724 Reduces the Amounts of Oral Pathogens and Alters the Oral Microbiota in Children With Dental Caries: a Randomized, Double-Blind, Placebo-Controlled Trial