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The medicinal herb fenugreek ( Trigonella foenum-graecum ) seeds, fortified with dietary fibers and furostanolic saponins including protodioscin, have demonstrated a significant contribution to human health. In our laboratories, Furosap ® , a patented 20% protodioscin-enriched extract was developed from fenugreek seeds. In an open-label, one-arm, single-center longitudinal study, we examined the safety and efficacy of Furosap ®  on free and total testosterone levels, fasting blood sugar, blood pressure, sperm count, motility and morphology, dihydroepiandrosterone sulfate (DHEA-S), sexual health, reflex erection, mood alleviation, mental alertness, and total blood chemistry analyses over a period of 12 weeks in healthy male volunteers. Institutional Ethics Committee approvals and Clinicaltrials.gov registration were obtained. Effect of Furosap ®  (500 mg/day) was examined of free and total testosterone levels, sperm count, motility and morphology, sexual health, mood and mental alertness, and total blood chemistry analyses in 100 healthy volunteers (age 35–60 Y) over a period of 12 consecutive weeks. No changes were observed in body weight and BMI. Both systolic and diastolic blood pressure, and DHEA levels significantly decreased. Free and bound testosterone levels improved significantly at 12 weeks of treatment. Sperm motility significantly increased at 8- and 12-weeks of treatment, while abnormal sperm morphology significantly decreased at 12-weeks of treatment. Mental alertness, mood, and reflex erection score significantly alleviated. An age-induced increasing effect was observed. Furthermore, cardiovascular health and libido significantly improved. Blood chemistry analyses exhibited broad spectrum safety. A decreasing trend was observed in total cholesterol, triglycerides, and VLDL levels, while an increasing trend was observed in HDL level at 12 weeks of treatment. LDL level decreased significantly at 12-weeks of treatment. No adverse events were observed. Results demonstrate that Furosap ®  is safe and effective in improving testosterone levels, cardiovascular health, healthy sperm profile, mental alertness in human male volunteers.

journal of the american nutrition association

Safety and Efficacy of Furosap®, a Patented  Trigonella foenum-graecum  Seed Extract, in Boosting Testosterone Level, Reproductive Health and Mood Alleviation in Male Volunteers