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Monocarboxylate transporters (MCTs) play vital roles in carbon source assimilation, drug resistance and virulence. However, the underlying function of MCTs in fungal pathogenesis and development has not been investigated in detail. In this study, we identified and characterized the monocarboxylate transporter gene  MCT1  of  Colletotrichum gloeosporioides , which is the causal agent of Glomerella leaf spot of apple. Mct1 is localized to the mitochondria and may mediate the uptake of lactate to the cell. However,  MCT1  was constitutively expressed but showed an enhanced expression level in response to the presence of the extracellular lactate. Our results indicate that Mct1 plays a role in the metabolism of lactate. More importantly, the Δ mct1  mutant showed significantly poor conidiation and a defect in host infection. Taken together, our studies provide evidence for Mct1 as a mitochondrial transmembrane protein mediating conidiation, the metabolism of lactate, and the pathogenicity of  C. gloeosporioides .

MCT1 plays crucial roles in conidiation, lactate metabolism and pathogenicity in Colletotrichum gloeosporioides