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In this work, a novel design of Zinc Oxide (ZnO) and bi-metallic (Ag–Au) layers based surface plasmon resonance (SPR) biosensor with barium titanate (BaTiO 3 ) and graphene is proposed. The proposed structure consists of SF10 glass prism, ZnO, Ag, Au, BaTiO 3 , and graphene as a top layer for biomolecules adsorption. Here, the performance of this structure is studied and analysed for sensitivity along with the accuracy of detection and quality parameter for the shift in refractive index (RI) from 1.33 (sensing medium) to 1.45 and our reported results show that addition of bimetallic (Ag–Au) layers along with BaTiO 3 , improve the sensitivity of the proposed structure to 14.85% for the same RI range compared to last reported MoS 2 -graphene-based SPR sensor. Here atmaximum sensitivity is reported as 116.67 degree/RIU while the accuracy of detection and the quality parameter are obtained as 4.54 and 37.87 RIU −1  respectively. These high-performance parameters of the design make this structure suitable for biosensing applications.

ZnO and Bi-metallic (Ag–Au) Layers Based Surface Plasmon Resonance (SPR) Biosensor with BaTiO 3 and Graphene for Biosensing Applications