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The objective of this study was to develop radiolabeled ibuprofen ( 99m Tc-ibu) for imaging and discrimination of inflammation and infection and compare its biodistribution in two different animal models. The development of radiolabeled ibuprofen as an imaging agent for inflammation and infection may have significant clinical implications for the diagnosis and management of various inflammatory and infectious diseases. This study provides a promising approach to the detection of sterile infections. Ibuprofen was radiolabeled with  99m Tc using the stannous chloride method with a yield of 99.05 ± 0.83% ( n  = 5). The  in vivo  biological behavior of radiolabeled ibuprofen was determined in Wistar albino rat models of sterile inflammation and bacterial infection with Staphylococcus aureus gram-positive bacteria. Biodistribution studies were carried out at different time points, and the results were compared between the two animal models. The uptake of  99m Tc-ibu in sterile inflammation sites at all time points was higher than that in the infection sites. This suggests that  99m Tc-ibu can be used to discriminate between sterile inflammation and bacterial infection. The results of this study suggest that the detection of sterile infections with  99m Tc-ibu is possible and highly encouraging.

In vivo behavior of technetium-99m labeled ibuprofen in infection and inflamation animal models