English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The present study aims to investigate the protective effect of  Euphorbia thymifolia  and  Euphorbia hirta  extracts on  in vitro  antioxidant activity and  in vivo  analysis on hepatic marker enzyme levels and histopathological changes in the liver of carbon tetrachloride (CCl 4 ) induced hepatotoxicity rats. This study includes 42 adult male Albino Wistar rats randomly divided into seven treatment groups, including control (basal diet, G1), CCl 4 -induced single dose (1.5 ml/kg, i.p.) as the negative control (G2), G1 supplemented with 300 mg/kg of ethanol extract of  E. thymifolia  (G3) and  E. hirta  (G4), G2 supplemented with 300 mg/kg of ethanol extract of  E. thymifolia  (G5),  E. hirta  (G6), and silymarin (25 mg/kg b.w.) used as a standard drug (G7) for 21-days experimental period. The ethanolic extracts of  E. thymifolia  and  E. hirta  exhibited potential  in vitro  antioxidant activity in a dose-dependent manner (25 μg/ml, 50 μg/ml, 100 μg/ml, 200 μg/ml and 250 μg/ml). Oxidative stress caused by CCl 4 -induced the liver damage, including changes in liver marker enzymes (aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase), enzymatic (superoxide dismutase and catalase), non-enzymatic antioxidants (lipid peroxides and glutathione) and hepatocellular alterations such as hydropic degeneration, irregular hepatocytes, and distention of the vein. Administration of  E. thymifolia  and  E. hirta  significantly ( p  &lt; 0.05) restored the enzyme activity along with the histology of the liver. The results from the current study demonstrate that  E. thymifolia  and  E. hirta  have the property of restoring hepatic redox capacity and antioxidant activities against CCl 4 -induced acute liver damage.

Protective effect of Euphorbia thymifolia and Euphorbia hirta against carbon tetrachloride-induced hepatotoxicity in Wistar rats