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A previously unknown hemoglobin (Hb) variant was detected during measurement of glycosylated Hb (Hb A 1c ) after the introduction of a new high performance liquid chromatography (HPLC) apparatus. Subsequent DNA sequencing revealed a heterozygous single nucleotide substitution at codon 79 (C&gt;A) on the β-globin gene changing an amino acid [β79(EF3)Asp→Glu;  HBB : c.240C&gt;A]. The new Hb variant was named Hb Kalundborg after the place of origin of the proband. Heterozygosity for this mutation appears to have no clinical significance in itself except for a possibly slightly lower oxygen affinity. However, it interferes with Hb A 1c  measurement by HPLC, causing a falsely high Hb A 1c  concentration when using the G11 apparatus with clinical implications possibly to follow.

Hb Kalundborg [β79(EF3)Asp→Glu; HBB : c.240C>a], a Possible Low-affinity Hemoglobin Variant Detected during Hb A 1c Measurement