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This study examined the effects of one-month naringin administration and exercise training on cognitive impairment and H 2 S signaling pathway in an Amyloid β (Aβ)-injected rat. Rats were divided into four groups: control group; rats underwent Aβ microinjection surgery, exercise group; rats underwent Aβ microinjection surgery and trained by treadmill for four weeks, naringin group; rats underwent Aβ microinjection surgery, and rats orally administrated 80 mg.kg −1  naringin for four weeks, naringin+exercise group; rats underwent Aβ microinjection surgery and were trained by treadmill for four weeks, and also, rats orally administrated 80 mg.kg −1  naringin for four weeks. After one month of treatment, spatial learning and memory were measured, and then hippocampi were sampled. S-adenosylmethionine (SAM), cystathionine-β-synthase (CBS), hydrogen sulfide (H 2 S) levels, and neuronal death were detected in the hippocampi of rats. Naringin and exercise improved spatial learning (latency time, P &lt; .001) and memory (P &lt; .001) in the Morris Water Maze test in Aβ-injected rats compared with the control group. SAM (P &lt; .01), CBS (P &lt; .001), and H 2 S (P &lt; .01) levels are increased in the naringin+exercise group compared with the control group. The result of this study supports the effect of exercise and/or naringin to improve cognitive dysfunction and cell death through the production of H 2 S.

Aerobic Training with Naringin Supplementation Improved Spatial Cognition via H 2 S Signaling Pathway in Alzheimer’s Disease Model Rats