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Avibacterium paragallinarum (A. paragallinarum)  is the aetiological agent of infectious coryza (IC) in chickens and characterized by acute respiratory distress and severe drop in egg production. Vaccination is important in the control of IC outbreaks and the efficacy of vaccination is dependent on  A. paragallinarum  serovars included in the vaccine. Classical serotyping of  A. paragallinarum  is laborious and hampered by poor availability of antigens and antisera. The haemagglutinin, important in classical serotyping, is encoded by the  HMTp210  gene.  HMTp210  gene analysis has been shown to have potential as alternative to classical serotyping. The aim of the present study was to further investigate the potential of sequence analyses of partial region 1 of the  HMTp210  gene, the  HMTp210  hypervariable region and the concatenated sequences of both fragments. For this analysis, 123  HMTp210  gene sequences (field isolates,  A. paragallinarum  serovar reference strains and vaccine strains) were included. Evaluation of serovar references and vaccine strains revealed a need for critical evaluation, especially within Page serovar B and C. Phylogenetic analysis of  HMTp210  region 1 resulted in a separation of Page serovar A, B and C strains. Analysis of the  HMTp210  HVR alone was not sufficient to discriminate all nine different Kume serovar references. The concatenated sequences of  HMTp210  region 1 and  HMTp210  HVR resulted in 14 clusters with a high correlation with Page serovar and with the nine currently known Kume serovars and is therefore proposed as a novel genotyping method that could be used as an alternative for classical serotyping of  A. paragallinarum .

avian pathology

Molecular characterization of the  HMTp210  gene of  Avibacterium paragallinarum  and the proposition of a new genotyping method as alternative for classical serotyping