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Avian pathogenic  E. coli  (APEC) can cause localized and systemic diseases in poultry, threatening human health via meat or egg contamination and resulting in considerable economic losses to the poultry industry globally. Increasing evidence shows circRNAs were widely involved in various biological processes. However, the role of circRNAs in the host response against APEC infection, especially correlated with the regulation of  RIP2 , remains unclear. Herein, the RNAseq technology was used to identify the circRNA expression profiles in the overexpression of  RIP2  macrophages with or without APEC infection. A total of 256 and 287 differentially expressed (DE) circRNAs were identified in the overexpression of  RIP2  group (oeRIP2) vs. the wild-type group (WT) and oeRIP2 + APEC vs. APEC, respectively, whose parental genes were involved in MAPK signalling pathway, Wnt signalling pathway, focal adhesion, tight junction, and VEGF signalling pathways. Specifically, the key circRNAs, such as 5:814443-825127, 10:18922360-18928461, 2:8746306-8750639, and 2:124177751-124184063 might play a critical role in APEC infection and the regulation of  RIP2 . As a whole, these findings will facilitate understanding the molecular mechanism underlying circRNAs, especially related to the regulation of the  RIP2  gene. Meanwhile, the study may offer new ideas to improve host immune and inflammatory response against APEC infection.

avian pathology

Genome-wide characterization of circRNA expression profile in overexpression of  RIP2  chicken macrophages associated with avian pathogenic  E.coli  infection