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The aim of this study was to evaluate the effects of anti-stress agents on the growth performance and immune function of broilers under immune stress conditions induced by vaccination. A total of 128, 1-day-old Arbor Acres broilers were randomly divided into four groups. Group normal control (NC) was the control group. Group vaccination control (VC), T 0.5%, and T 1% were the treatment groups, which were nasally vaccinated with two doses of the Newcastle disease virus (NDV) vaccine. The chicks in groups T 0.5% and T 1% were fed conventional diets containing 0.5% and 1% anti-stress agents. Thereafter, these broilers were slaughtered on 1, 7, 14, and 21 days post-vaccination. The results indicated that anti-stress agents could significantly reduce serum adrenocorticotropic hormone (ACTH) ( P  &lt; 0.01) and cortisol (CORT) ( P  &lt; 0.05) levels, and improve the growth performance ( P  &lt; 0.05) and immune function of broilers ( P  &lt; 0.05); However, the levels of malondialdehyde (MDA) ( P  &lt; 0.05) were decreased, and the decreased total antioxidant capacity (T-AOC) ( P  &lt; 0.01) levels mediated by vaccination were markedly improved. In addition, anti-stress agents could attenuate apoptosis in spleen lymphocytes ( P  &lt; 0.01) by upregulating the ratio of Bcl-2 to BAX ( P  &lt; 0.01) and downregulating the expression of caspase-3 and -9 ( P  &lt; 0.01), which might be attributed to the inhibition of the enzymatic activities of caspase-3 and -9 ( P  &lt; 0.05). In conclusion, anti-stress agents may improve growth performance and immune function in broilers under immune-stress conditions. RESEARCH HIGHLIGHTSInvestigation of effects and mechanism of immune stress induced by vaccination.Beneficial effect of anti-stress agents on growth performance, immune function, oxidative stress, and regulation of lymphocyte apoptosis.Demonstration of the effects of apoptosis on immune function in the organism. Investigation of effects and mechanism of immune stress induced by vaccination. Beneficial effect of anti-stress agents on growth performance, immune function, oxidative stress, and regulation of lymphocyte apoptosis. Demonstration of the effects of apoptosis on immune function in the organism.

Effects of anti-stress agents on the growth performance and immune function in broiler chickens with vaccination-induced stress