English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Mycoplasma gallisepticum  is the primary causative agent of chronic respiratory disease in poultry, and vaccination is the measure most commonly used for its control. Pathological changes caused by  M. gallisepticum  are mainly observed in the trachea and air sacs, but assessment of air sac lesions is subjective. Standardized parameters for evaluation of pathological changes, and their reproducibility and discrimination in uninfected and infected groups, are critical when assessing the efficacy of  M. gallisepticum  vaccination. This study reviewed and critically appraised the published literature on evaluation of vaccine efficacy against pathological changes caused by  M. gallisepticum  in poultry in the trachea and air sacs. A search of four electronic databases, with subsequent manual filtering, identified 23 eligible papers published since 1962 describing the assessment of histopathological changes in the trachea using tracheal lesion scores and/or measurement of tracheal mucosal thicknesses and assessment of gross air sac lesions using lesion scores. Measurement of tracheal lesions proved a more reliable and robust method of assessing disease induced by  M. gallisepticum  when compared to assessment of air sac lesions, highlighting the importance of including assessment of tracheal lesions as the primary outcome variable in vaccine efficacy studies. In addition, this study also identified the necessity for use of a standardized model for evaluation and reporting on  M. gallisepticum  vaccines to minimize variations between vaccine efficacy studies and to allow direct comparisons between them. RESEARCH HIGHLIGHTSTracheal and air sac lesions have been used to assess  M. gallisepticum  vaccine efficacy.The specific parameters and statistical tests used to compare tracheal and air sac lesions vary greatly.Measures of tracheal lesions are more discriminatory than measures of air sac lesions.A standardized model is needed to evaluate vaccines against infection with  M. gallisepticum . Tracheal and air sac lesions have been used to assess  M. gallisepticum  vaccine efficacy. The specific parameters and statistical tests used to compare tracheal and air sac lesions vary greatly. Measures of tracheal lesions are more discriminatory than measures of air sac lesions. A standardized model is needed to evaluate vaccines against infection with  M. gallisepticum .

avian pathology

Measures of tracheal lesions are more discriminatory and reproducible indications of chronic respiratory disease caused by  Mycoplasma gallisepticum  in poultry