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Alu  insertions are bi-allelic and primate-specific, this makes them a useful marker for studying genetic variation, migration patterns, forensic analyses, paternity, and evolutionary heritage; however, specific population studies are limited. The objective of this study is to document the level and extent of genetic variation at 39 different  Alu  loci in five populations (British, Indian Punjabi, Indian Gujarati, Pakistani, and Bangladeshi) from the East Midlands region of the UK. Genetic data on migrant populations is currently limited. DNA samples ( n  = 543) were analysed for 39  Alu  insertion polymorphisms using specific primers and standard protocols. Data were analysed for population and forensic genetic parameters. All studied  Alu s were polymorphic in the British White population while South Asian migrant populations had a variable number of loci which were monomorphic. Highest heterozygosities and lowest match probabilities were observed in the British sample, while the Bangladeshi sample had the lowest heterozygosity and higher match probability. The analysed  Alu s insertions (TPA25, Ya5NBC123, Ya5NBC182, Ya5NBC241, and Ya5NBC242) are highly polymorphic and variable among migrant populations. These loci could be useful for population genomic and differentiation studies.

Genomic diversity and differentiation of Alu insertion polymorphisms in a native British and four South Asian migrant populations