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Organic anion-transporting polypeptide 1B1 (OATP1B1) and the ATP-binding cassette subfamily G member 2, ABCG2, are important transporters involved in the transport of endogenous substrates and xenobiotics, including drugs. Genetic polymorphisms of these transporters have effect on transporter activity. There is significant interethnic variability in the frequency of allele variants. To determined allele and genotype frequencies of  ABCG2  and  SLCO1B1  genes in Croatian populations of European descent. A total of 905 subjects (482 women) were included. Genotyping for  ABCG2  c.421C &gt; A (rs2231142) and for  SLCO1B1  c.521T &gt; C (rs4149056), was performed by real-time polymerase chain reaction (PCR) using TaqMan ®  DME Genotyping Assays. For  ABCG2  c.421C &gt; A, the frequency of CC, CA and AA genotypes was 81.4%, 17.8% and 0.8% respectively. The frequency of variant  ABCG2  421 A allele was 9.7%. For  SLCO1B1  c.521T &gt; C, the frequency of TT, TC and CC genotypes was 61.7%, 34.8% and 3.5% respectively. The frequency of variant  SLCO1B1  521 C allele was 20.9%. The frequency of the ABCG2 and SLCO1B1 allelic variants and genotypes in the Croatian population is in accordance with other European populations. Pharmacogenetic analysis can serve to individualise drug therapy and minimise the risk of developing adverse drug reactions.

ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population