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We hypothesized that children with obesity-related asthma would have worse self-reported asthma control, report an increased number of asthma symptoms and have lower FEV 1 /FVC associated with worse clinical asthma outcomes compared to children with asthma only. Cross sectional analyses examined two hundred and eighteen (obesity-related asthma = 109, asthma only = 109) children, ages 7–15 that were recruited from clinics and hospitals within the Bronx, NY. Pulmonary function was assessed by forced expiratory volume in the first second (percent predicted FEV 1 ) and the ratio of FEV 1  to the forced vital capacity of the lungs (FEV 1 /FVC). Structural equation modeling examined if pulmonary function was associated with asthma control and clinical outcomes between groups. Lower percent predicted FEV 1  was associated with increased hospitalizations ( p  = 0.03) and oral steroid bursts in the past 12 months ( p  = 0.03) in the obesity-related asthma group but not in the asthma only group. FEV 1 /FVC was also associated with increased hospitalizations ( p  = 0.02) and oral steroid bursts ( p  = 0.008) in the obesity-related asthma group but not the asthma only group. Lower FEV 1 /FVC was associated with the number of asthma symptoms endorsed in the asthma only group but not in the obesity-related asthma group. Percent predicted FEV 1  and FEV 1 /FVC was not associated with asthma control in either group. Pulmonary function was associated with oral steroid bursts and hospitalizations but not self-reported asthma control, suggesting the importance of incorporating measures of pulmonary function into the treatment of pediatric obesity-related asthma.

Obesity-related pediatric asthma: relationships between pulmonary function and clinical outcomes