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Objective:  The optimal use of drug combinations for the management of asthma is providing significant results. This has prompted Interasma (Global Asthma Association) to take a position on inhaled triple therapy in asthma. Methods:  We performed an extensive literature research to clinical trials, meta-analyses, randomized controlled trials and systematic reviews. Results:  Starting from an extensive literature review, Interasma executive committee discussed and approved this Manifesto, developed by Interasma scientific network (INES) members. Conclusions:  The manifesto describes the evidence gathered to date and states, advocates, and proposes issues on inhaled corticosteroid (ICS) plus long-acting beta 2 agonist (LABA) and long-acting muscarinic antagonists (LAMA) with the aim of challenging assumptions, fostering commitment, and bringing about change.

Manifesto on inhaled triple therapy in asthma: an Interasma (Global Asthma Association – GAA) document