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Objective of the research was to potentiate solubility of Rosuvastatin by nanogels synthesized by free radical polymerization. Surface morphology and structural compatibility were studied through scanning electron microscopy (SEM) and Fourier Transform Infrared (FTIR) spectroscopy. Zeta sizer was used for particle size analysis. Swelling,  in-vitro  release and solubility studies were accomplished in different media. Similarly, results of  in-vitro  release of nanogels and commercially available tablets of Rosuvastatin were compared in different dissolution media. Biocompatibility study was performed in healthy rabbits for safety profile. FTIR spectroscopy confirmed the presence of corresponding peaks of respective functional groups of individual constituents and that of the drug in unloaded and loaded nanogels. SEM images depicted the fluffy appearance of nanogels with small pores inside the structure. Particle size of the optimized formulation was in the range of 217.70 ± 2.23 for unloaded and 257.33 ± 2.11 for loaded nanogels. Percent drug loading,  in-vitro  drug release and solubility profiles were also satisfactory. In comparison with commercially available tablet Rovista®,  in-vitro  release profiles of synthesized nanogels showed better response. Moreover, synthesized nanogels were also biocompatible. It was concluded that the solubility of Rosuvastatin was potentially enhanced by nanogels and such formulation can also be used for other poorly soluble drugs.

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Structural and  in-vitro  characterization of highly swellable β-cyclodextrin polymeric nanogels fabricated by free radical polymerization for solubility enhancement of rosuvastatin