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The objective of the present study is to develop, a hitherto unreported, novel, and sustainable protocol to synthesize copper oxide nanoparticles (CuO NPs) using  Jasminum sambac  flower extract. CuO NPs of diverse shapes and sizes were obtained using four different copper salt precursors, namely copper sulfate pentahydrate, copper chloride dihydrate, copper nitrate trihydrate, and copper acetate monohydrate while maintaining similar synthetic conditions. XRD analysis reveals that the crystallite sizes of NPs are in the range of 5.25–55.01 nm. FTIR has predicted that biomolecules serve as stabilizing as well as capping agents during the nucleation of NPs. The presence of broad absorption peaks, resulting from surface plasmon resonance, was observed in UV-Vis spectra. The FE-SEM images depicted the diverse morphologies of NPs, which were actually governed by the copper salt precursors. The EDS investigations endorse the dominant peaks corresponding to Cu and O. The analysis of antimicrobial activity was carried out to confirm their aptitude for biomedical applications. It was found that the analogy between the shape of bacteria and that of nanostructure resulted in efficient anti-bacterial activity. The toggle-shaped NPs of CuO derived out of copper sulfate precursor exhibited the best antibacterial activity.

Efficient antibacterial activity in copper oxide nanoparticles biosynthesized via Jasminum sambac flower extract