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Silver nanoparticles (AgNPs) have big potentials in designing next-generation anticancer and antimicrobial agents. Here, AgNPs were synthesized with green chemistry using edible mushrooms  Schizophyllum commune  and  Geopora sumneriana . The synthesized AgNPs were characterized with ultraviolet-visible spectrophotometry (UV–Vis), Fourier transform infrared spectrophotometer (FTIR), scanning transmission electron microscope (S-TEM), energy dispersive spectrometry (EDS), x-ray diffraction (XRD), and dynamic light scattering (DLS) techniques. Anticancer activities of the synthesized  S. commune  (SC-AgNPs) and  G. sumneriana  (GS-AgNPs) were studied on the breast (MCF-7), lung (A549), colon (HT-29), and liver (HUH-7) cancer cell lines. Also, the antimicrobial potential of SC-AgNPs and GS-AgNPs was determined against pathogens bacteria ( Pseudomonas aeruginosa ,  Klebsiella pneumonia ,  Staphylococcus aureus , and  Enterococcus faecalis ) and fungal ( Candida albicans  and  Candida utilis ) strains. Obtained results demonstrated that the synthesized SC-AgNPs and GS-AgNPs have anticancer and antimicrobial activity. Our study implicates that SC-AgNPs and GS-AgNPs have great potentials for the treatment of cancer and infectious diseases.

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Green synthesis of silver nanoparticles using  Schizophyllum commune  and  Geopora sumneriana  extracts and evaluation of their anticancer and antimicrobial activities