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Anacardium occidentale  (AO) possesses potent anti-diabetic properties, owing to its high phytochemicals content. This study attempted to maximise the efficacy of AO by encapsulating it in a solid lipid microparticle (SLMs) formulation.  L ea ves of AO  were extracted with water and formulated  into SLMs  u sing a lipid matrix composed of P90H  and Dika fat. Characterisation  of the SLMs include  morphology, particle size, pH, encapsulation efficiency percentage,  in vitro  re lease and anti-diabetic properties . SLMs were spherical with sizes ranging from 16.7 ± 0.8 µm to 40.12 ± 2.34 µm and had a fairly stable pH over time. Highest drug entrapment was 87% .  Batch A 2  exhibited an even release of 89%, sustained over time, and a mean percentage reduction in glucose of 25.9% at 12 h after oral administration to study animals.  Anacardium occidentale -loaded SLMs exhibited a good hypoglycaemic effect and can be used in the management of diabetes.

Development and formulation of antidiabetic property of Anarcadium occidantale -based solid lipid microparticles