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Baclofen and Lamotrigine via PLGA nanoparticles were developed for nose-to-brain delivery for the treatment of Neuropathic pain. Nanoparticles were prepared using the modified nano-precipitation method. The prepared NPs were characterised and further  in vitro  and  in vivo  studies were performed. The Bcf-Ltg-PLGA-NPs were ∼177.7 nm with &gt;75%(w/w) drugs encapsulated.  In vitro  dissolution studies suggested zero-order release profiles following the Korsmeyer-Peppas model.  In vitro  cytotoxicity and staining studies on mammalian cells showed dose dependant cytotoxicity where nanoparticles were significantly less toxic (&gt;95% cell-viability). ELISA studies on RAW-macrophages showed Bcf-Ltg-PLGA-NPs as a potential pro-inflammatory-cytokines inhibitor.  In vivo  gamma-scintigraphy studies on rats showed intra-nasal administration of  99m Tc-Bcf-Ltg-PLGA-NPs showed  Cmax  3.6%/g at  Tmax  = 1.5h with DTE% as 191.23% and DTP% = 38.61% in brain. Pharmacodynamics evaluations on C57BL/6J mice showed a significant reduction in licks/bites during inflammation-induced phase II pain. The findings concluded that the combination of these drugs into a single nanoparticle-based formulation has potential for pain management.

journal of microencapsulation

In vitro  &amp;  in vivo  evaluations of PLGA nanoparticle based combinatorial drug therapy for baclofen and lamotrigine for neuropathic pain management