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Aims:  To evaluate the feasibility and acceptability of vibration therapy (VT) in preschool children with cerebral palsy (CP) and obtain preliminary data on its potential effectiveness. Methods:  Nine children aged 2.5–4.8 years (4 boys) with CP GMFCS levels I–III participated in a single-group feasibility study, undergoing a 12-week control period without intervention, followed by 12 weeks of home-based VT (four times/week, 9 min/day, frequency 20 Hz). We assessed adherence to VT protocol, adverse events, and family acceptability of VT. Clinical assessments included motor function (GMFM-66), body composition (DXA), mobility (10-meter walk/run test), and health-related quality of life (PedsQL). Results:  VT was well tolerated and acceptable to families, with high adherence levels reported (mea n =  93%). There were no observed between-period differences (ΔControl vs ΔVT) except for an improvement in the PedsQL "Movement &amp; Balance" dimension with VT (p = 0.044). Nonetheless, changes after the VT but not the Control period were suggestive of potential treatment benefits for mobility, gross motor function, and body composition (lean mass and legs bone mineral density). Conclusion:  Home-based VT is feasible and acceptable for preschool children with CP. Our preliminary data suggest potential health benefits from VT for these children, supporting larger randomized trials to assess its effectiveness properly.  Clinical trial registration number:  Australian New Zealand Clinical Trials Registry (ACTRN12618002027291)

Vibration Therapy as an Early Intervention for Children Aged 2–4 Years with Cerebral Palsy: A Feasibility Study