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Nanocochleates (NCs) are amongst the nanoformulations gaining wide popularity owing to their ability to improve biopharmaceutical performance of drug molecules remarkably. However, biggest drawback of this nanocarrier is that it requires minimum two steps for synthesis which limits its industrial scalability. Considering the same, the present work was designed with an objective to assess suitability of electrospray technique in the preparation of biomaterial based NCs. Glipizide (GPZ) was chosen as a model drug for preparation of NCs. Briefly, GPZ, phosphatidylcholine and cholesterol were dissolved in methanol and co-axially sprayed into a pool of CaCl 2  solution. Factorial design (2 2 ) approach was used for batch optimization. The optimized batch was evaluated for surface morphology, FTIR, DSC, zeta potential,  in-vitro  drug release study and  in-vivo  evaluation in male wistar rats. FESEM images confirmed formation of NCs using electrospray technique. Negative zeta potential (-14.36 ± 0.55 mV) of optimized batch reflected high stability of the sample. GPZ was released in a controlled manner from the optimized GPZNC.  In-vivo  pharmacokinetic study demonstrated significant increase in C max  (2-fold) and AUC (3-fold) upon entrapment of GPZ into NCs. Thus, the present work unfolded suitability of electrospray technology toward single step preparation of Phosphatidylcholine and Cholesterol biomaterial based nanocochleates over currently used two step preparation techniques.

Electrospray technology as a probe for single step fabrication of glipizide loaded nanocochleates with enhanced bioavailability