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Alterations to the  LRRK2  gene have been associated with Parkinson’s disease and alcohol consumption in animals and humans. Furthermore, these disorders are strongly related to anxiety disorders (ADs). Thus, we investigated how the  LRRK2  gene might influence anxiety in humans and mice. We elaborated a systematic review based on the  PRISMA  Statement of studies that investigated levels of anxiety in animal or human models with alterations in the  LRRK2  gene. The search was conducted in the PubMed, Scopus, and Web of Science databases, and in reference lists with descriptors related to ADs and the  LRRK2 . From the 62 articles assessed for eligibility, 16 were included: 11 conducted in humans and seven, in mice.  Lrrk2  KO mice and the  LRRK2  G2019S,  LRRK2 R1441G , and  LRRK2  R1441C variants were addressed. Five articles reported an increase in anxiety levels concerning the  LRRK2  variants. Decreased anxiety levels were observed in two articles, one focusing on the  LRRK2  G2019S and the other, on the  Lrrk2  KO mice. Eight other articles reported no differences in anxiety levels in individuals with  Lrrk2  alterations compared to their healthy controls. This study discusses a possible influence between the  LRRK2  gene and anxiety, adding information to the existing knowledge respecting the influence of genetics on anxiety.

Possible association between the lrrk2 gene and anxiety behavior: a systematic literature review