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The aim of this study was to explore the relationship between sensory profiles and the quality of life. Methods: A cross-sectional study was conducted with 99 participants, with a diagnosis of schizophrenia. Adolescent/Adult Sensory Profile, the WHOQOL-BREF and PANSS were administered. A stepwise linear regression analysis was performed, with those variables of the sensory profile and the dimensions of quality of life that showed a statistically significant correlation. Participants with lower quality of life (WHOQOL-Bref score ≤ 60) showed a higher score in Low Registration profile ( t (97) = 2;  p  = .048;  δ  = .42). Physical Health showed a moderate negative correlation with Sensory Sensitivity profile ( r  = −.415;  p  &lt; .01) and Sensation Avoiding ( r  = −.372;  p  &lt; .05). Psychological Health showed a moderate negative correlation with Low Registration ( r  = −.354;  p  &lt; .01), Sensory Sensitivity ( r  = −.307;  p  &lt; .01) and auditory processing ( r  = −.343;  p  &lt; .01). Sensory preference could be a key aspect of mental health rehabilitation programs. Sensory modulation issues seem to be related to the quality of life of patients with schizophrenia. KEY POINTSSensory preference could be a key aspect of mental health rehabilitation programs.Mental health services should consider the sensory profile of the patient in the evaluation and intervention.Sensory modulation approaches could be complementary interventions to improve the quality of life of people with schizophrenia. Sensory preference could be a key aspect of mental health rehabilitation programs. Mental health services should consider the sensory profile of the patient in the evaluation and intervention. Sensory modulation approaches could be complementary interventions to improve the quality of life of people with schizophrenia.

Relationship between Sensory Profile and Self-Perceived Quality of Life in People with Schizophrenia: An Exploratory Study