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Inconsistent findings have emerged from epidemiological research investigating the association between vitamin B 6  and the risk of gastric cancer. To obtain a more precise assessment, we conducted a comprehensive search of published data and performed a meta-analysis. PubMed, Web of Science, EMBASE and Cochrane Library databases were systematically searched. A total of 12 studies (5 prospective cohort and 7 case–control studies) involving 5,692 cases and 814,157 participants were included in the meta-analysis. The results showed that high intake of vitamin B 6  may reduce the odds of gastric cancer (OR = 0.83, 95% CI: 0.73–0.95,  p  = 0.006). However, this association was only observed in the case–control studies (OR = 0.68, 95% CI: 0.51–0.89,  p  = 0.006) but not in the cohort studies (RR = 1.01, 95% CI: 0.94–1.08,  p  = 0.819). Additionally, the negative association between vitamin B 6  intake and gastric cancer risk was found in the United States of America (OR = 0.71, 95% CI: 0.62–0.82,  p  = 10 −4 ), but not in Europe (OR = 0.88, 95% CI: 0.74–1.05,  p  = 0.169) or the other regions (OR = 0.86, 95% CI: 0.66–1.13,  p  = 0.280). In conclusion, there is not sufficient evidence to assume that vitamin B 6  intake is associated with gastric cancer risk, which needs further confirmation.

Association between Vitamin B 6 and Risk of Gastric Cancer: A Systematic Review and Meta-Analysis of Epidemiological Studies