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This meta-analysis aimed to assess the association between vitamin B6 intake, blood PLP levels, and the risk of colorectal cancer. The databases PubMed, Cochrane Library and Embase databases were comprehensively searched for cohort studies or case-control studies. The odds ratio (OR) and 95% confidence interval (CI) were extracted from each eligible study, and the statistical software Stata was used to perform statistical merging. Twenty-eight studies (20 cohort studies, 8 case-control studies) were included in our meta-analysis. The combined OR for the association between colorectal cancer risk and vitamin B6 intake was 0.80 (95% CI: 0.68–0.94), while the combined OR between blood PLP levels and colorectal cancer risk was 0.54 (95% CI: 0.35–0.84). In addition, the subgroup analysis revealed that vitamin B6 could reduce the risk of colorectal cancer in women [vitamin B6 intake OR = 0.79, 95% CI (0.65–0.96); blood PLP levels OR = 0.41, 95% CI (0.30–0.57)] and also reduce the risk of colon cancer in men and women [vitamin B6 intake OR = 0.76, 95% CI (0.64–0.91); blood PLP levels OR = 0.56, 95% CI (0.42–0.73)]. In this meta-analysis, vitamin B6 intake and blood PLP levels were inversely associated with colorectal cancer risk.

Association Between Vitamin B6 and the Risk of Colorectal Cancer: A Meta-analysis of Observational Studies