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Gamma-knife radiosurgery (GKRS) is an alternative treatment option for selected intracranial meningiomas. The study’s aim is to demonstrate the advantages of T1-weighted perfusion magnetic resonance imaging (T1-PMRI) by measuring the volume transfer coefficient (K trans ) values in the prediction of local response for patients with meningioma who have undergone GKRS consecutively. The data of patients diagnosed radiologically with WHO grade 1 intracranial meningiomas was collected prospectively. The patients who were treated consecutively with GKRS at our institution (September 2017–September 2018) were included. After GKRS, the patients were followed up at the defined periods with routine contrast-enhanced MRI and T1-PMRI by measuring the K trans . The comparison between the pre-treatment and third-month post-treatment (PO3M) K trans  was done using the Wilcoxon signed-rank test. Thirty-one patients with 36 tumors have undergone GKRS. Twenty-two patients were female. The mean age was 55.3 years. The mean pre-GKRS volume was 7.67 ccs. The mean 50% radiation isodose was 12.2 Gy. The local tumor control rate was 100%. Fourteen tumors were regressed fully at the last MRI. PO3M K trans  decreased when compared with the pre-GKRS values ( p  &lt; 0.0001). However, the numerical decrease in tumor volumes on contrast-enhanced MRI was not statistically significant ( p  = 0.117). Changes between K trans  on PO3M and pre-GKRS T1-PMRI were more useful in determining the early response to GKRS in patients with meningioma than volumetric changes. Therefore, K trans  should be taken as a reference to predict the early response to GKRS in follow-up imaging scans.

neurological research

Early stage T1-weighted perfusion magnetic resonance imaging: a factor that predicts local control response in patients with meningioma who underwent gamma-knife radiosurgery