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Myxoid liposarcoma (MLPS) has different patterns that are often difficult to distinguish from other soft tissue lesions. MLPS is characterized by a reciprocal translocation involving the DNA Damage Inducible Transcript 3 gene  (DDIT3)  that can be detected using fluorescent in situ hybridization (FISH). Recently, the marker for cancer testis antigen 1b (CTAG1B) was found to be expressed in MLPS. The aim of the present study was to assess the potential use immunohistochemistry (IHC) for CTAG1B expression and  DDIT3  rearrangement to diagnose MLPS and distinguish it from similar lesions. Out of 29 cases including MLPS and its mimics, CTAG1B was expressed in 92.86% of cases of MLPS and 20% of its mimics.  DDIT3  rearrangement was 100% sensitive and 92.86% specific in distinguishing MLPS from its mimics. The  DDIT3  rearrangement was found to be more sensitive but less specific than cytoplasmic expression of CTAG1B marker.  DDIT3  polysomy and amplification were detected in some cases. Therefore, both CTAG1B expression and FISH for  DDIT3  gene can be used to distinguish MLPS from similar tumors. The use of both immunohistochemistry for CTAG1B in addition to  DDIT3  gene rearrangement detection by FISH was more specific than using either of them alone. However, the  DDIT3  gene rearrangement alone was the most sensitive test for distinguishing MLPS from its mimics.

journal of histotechnology

Expression of CTAG1B clone EPR13780 versus  DDIT3  gene rearrangement distinguishes myxoid liposarcoma from its mimics with detection of novel  DDIT3  gene copy number variations