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This retrospective cohort study explored the morphological features of chronic endometritis (CE) and pregnancy outcomes during in vitro fertilization (IVF) in women with CE (429) at Yantai Yuhuangding Hospital between January 2017 and September 2018. The primary outcome was the clinical pregnancy rate (CPR). The women displayed haemorrhagic spots (175), hyperaemia (122), micropolyps (75), hyperaemia combined with micropolyps (49) and others (8). The CPR and live birth rate (LBR) were different among the hysteroscopic features of CE in fresh embryo transfer cycles ( p =  .002,  p =  .011). The miscarriage and premature birth rates were not significantly different among groups ( p  &gt; .05). Hyperaemia (0.47 [95% CI, 0.29; 0.77]), micropolyps (0.40 [95% CI, 0.23; 0.72]), hyperaemia combined with micropolyps (0.35 [95% CI, 0.18; 0.69]) and others (0.36 [95% CI, 0.19; 0.69]) were associated with the CPR. In conclusion, the hysteroscopic features of CE are associated with IVF pregnancy outcomes, and there were differences in pregnancy outcomes with different CE hysteroscopic features.IMPACT STATEMENTWhat is already known on this subject?  Chronic endometritis (CE) is associated with adverse pregnancy outcomes such as infertility, premature delivery and miscarriage. CE can reduce the success rate of pregnancy and even lead to obstetric and neonatal complications, and is an adverse factor for the success of in vitro fertilization (IVF). There are different types of CE, but their impact on IVF outcomes is unknown.What the results of this study add?  The CPR and LBR were different among the hysteroscopic features of CE in fresh embryo transfer cycles ( p  = .002,  p  = .011). The miscarriage and premature birth rates were not significantly different among groups ( p  &gt; .05). After adjustment, the multivariable analysis showed that hyperaemia (OR = 0.47,  p  = .002), micropolyps (OR = 0.40,  p  = .002), hyperaemia combined with micropolyps (OR = 0.35,  p  = .002) and others (OR = 0.36,  p  = .002) were associated with the CPR among patients with CE.What the implications are of these findings for clinical practice and/or further research?  The hysteroscopic features of CE are associated with IVF pregnancy outcomes, and there were differences in pregnancy outcomes with different CE hysteroscopic features. Hence, women with repeated IVF failure should undergo hysteroscopy to examine for the presence of CE and its nature. What is already known on this subject?  Chronic endometritis (CE) is associated with adverse pregnancy outcomes such as infertility, premature delivery and miscarriage. CE can reduce the success rate of pregnancy and even lead to obstetric and neonatal complications, and is an adverse factor for the success of in vitro fertilization (IVF). There are different types of CE, but their impact on IVF outcomes is unknown. What the results of this study add?  The CPR and LBR were different among the hysteroscopic features of CE in fresh embryo transfer cycles ( p  = .002,  p  = .011). The miscarriage and premature birth rates were not significantly different among groups ( p  &gt; .05). After adjustment, the multivariable analysis showed that hyperaemia (OR = 0.47,  p  = .002), micropolyps (OR = 0.40,  p  = .002), hyperaemia combined with micropolyps (OR = 0.35,  p  = .002) and others (OR = 0.36,  p  = .002) were associated with the CPR among patients with CE. What the implications are of these findings for clinical practice and/or further research?  The hysteroscopic features of CE are associated with IVF pregnancy outcomes, and there were differences in pregnancy outcomes with different CE hysteroscopic features. Hence, women with repeated IVF failure should undergo hysteroscopy to examine for the presence of CE and its nature.

journal of obstetrics and gynaecology

Association between hysteroscopic features of chronic endometritis and pregnancy outcomes of patients after in vitro fertilization: a retrospective cohort study