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Eleven new and three reported half-sandwich Ru(II) arene complexes were synthesized using [Ru(η 6 -benzene)Cl(μ-Cl)] 2  and [Ru(η 6 -toluene)Cl(μ-Cl)] 2  and four pyridine carboxylic acid-based ligands (dicarboxylic acids and halogen derivatives). The structures and purity of synthesized compounds were confirmed using  1 H and  13 C NMR spectroscopy, infrared spectroscopy, mass spectrometry, and elemental analysis. The stability of synthesized compounds in dimethyl sulfoxide solution was confirmed using  1 H NMR spectroscopy. The seven ligands, two complex precursors ( CP1  and  CP2 ), and 14 half-sandwich Ru(II) picolinate complexes ( C1–C14 ) were evaluated for  in vitro  antibacterial and antifungal activity against pathogens, such as  Staphylococcus aureus ,  Bacillus cereus ,  Proteus mirabilis ,  Klebsiella pneumoniae ,  Ecsherichia coli ,  Pseudomonas aeruginosa ,  Salmonella enteritidis ,  Enterobacter aerogenes , and yeast  Candida albicans , using the microwell-dilution method. Among the tested samples, the ligands showed better inhibitory effect against Gram-positive bacteria when compared to the metal complexes. The most susceptible Gram-negative bacteria was  Ecsherichia coli , with a MIC value of 1.25 mg/mL, for  C3 ,  C6 , and  C10 . All synthesized complexes showed similar, slightly better activity against  Candida albicans .

Synthesis, chemical characterization, and antimicrobial potency of picolinate-based half-sandwich Ru(II) complexes