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Cancer is a fast-growing disease responsible for many deaths worldwide. Due to its aggressive and forever-changing nature, it is imperative to find alternative anti-cancer agents that could possibly treat this disease. Silver(I) phosphine complexes were synthesized by reaction of AgNO 3 , AgCl, and AgBr with cyclohexyldiphenylphosphine to produce 1:1, 1:2, or 1:3 molar ratios of new silver complexes with the formulas [Ag(PPh 2 Cy)NO 3 ] ( 1 ), [Ag(PPh 2 Cy) 2 NO 3 ] ( 2 ), [Ag(PPh 2 Cy) 3 NO 3 ] ( 3 ), [Ag(PPh 2 Cy) 2 Cl] ( 4 ), [Ag(PPh 2 Cy) 3 Cl] ( 5 ), and [Ag(PPh 2 Cy) 3 Br] ( 6 ), respectively. The complexes were characterized by elemental analyses, FT-IR and  1 H,  13 C,  31 P NMR spectroscopic techniques. The crystal structures of  5  (CCDC 1480482) and  6  (CCDC 2183297) were determined by single-crystal X-ray diffractometry. All six complexes were evaluated as potential anti-cancer agents in four different human malignant (SNO, MCF-7, A375, and A549) cell lines and one human non-malignant (HEK293) cell line. Overall, these complexes were significantly cytotoxic to both cancerous and non-cancerous cells and are therefore not considered suitable anti-cancer agents in their current form.

journal of coordination chemistry

Synthesis, crystal structure and spectral studies of silver(I) cyclohexyldiphenylphosphine complexes: towards the biological evaluation on malignant and non-malignant cells