English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A series of Zn(II) complexes ( 1 - 4 ) supported by thiophenyl- and furyl-derived  N , N -diamines ligands,  L 1 -L 4, where  L 1= 2,2-dimethyl- N 1 ,N 3 - bis(thiophen-2-ylmethyl)propane-1,3-diamine,  L 2=  N 1 ,N 3 - bis(thiophen-2-ylmethyl)propane-1,3-diamine,  L 3=  N 1, N3 -bis(furan-2-ylmethyl)-2,2-dimethylpropane-1,3-diamine, and  L 4=  N1 , N3 -bis(furan-2-ylmethyl)propane-1,3-diamine, were synthesized and characterized. Structural studies of  2  and  4  revealed a distorted tetrahedral geometry around the Zn(II) center. The synthesized ligands and their corresponding Zn(II) complexes were tested  in vitro  for urease inhibitory potential against  Jack bean urease  (JB urease) and  Bacillus pasteurii urease  (BP urease). Complex  2 , possessing a thiophenyl pendant moiety, exhibited considerable inhibitory potential against JB urease (IC 50  = 5.5 ± 0.15 μM) and BP urease (IC50 = 6.0 ± 0.12 μM) relative to the standard thiourea (IC 50  = 10 ± 0.52 and 8.20 ± 0.90 μM, respectively). Additionally, molecular docking confirmed the probable binding modes of the active complexes in the crystal structure of the JB urease. The synthesized ligands and complexes were also screened for anti-leishmanial activity and were proven to be effective against the  Leishmania  parasite.

Urease inhibition and anti-leishmanial properties of Zn(II) complexes of thiophenyl and furyl-derived C 2 -symmetric ligands