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One new binuclear Ni(II) complex with the molecular formula [Ni 2 (L) 2 (SCN) 2 (μ-SCN) 2 ] ( 1 ) has been synthesized using a tridentate Schiff base ligand (L), formed by the condensation between quinoline-2-carboxaldehyde and  N,N -dimethylethylenediamine. Complex  1  was characterized by FT-IR, UV-vis, and ESI-mass spectroscopy techniques, as well as elemental analysis, cyclic voltammetry, and single-crystal X-ray crystallography. The X-ray diffraction analysis of  1  indicated a centrosymmetric complex with nickel(II) centers in a distorted octahedral geometry and double bridged by thiocyanate anions  via  end-to-end ( μ -1,3) fashion. The interaction of  1  with CT-DNA was explored by UV-vis and fluorescence spectroscopy, viscosity and cyclic voltammetry which indicated a moderate intercalation of the complex with CT-DNA. The protein binding study of  1  with BSA and HSA was investigated by various spectroscopic methods and indicated a static quenching process. In addition,  1  showed prominent  in vitro  cytotoxic activity against human melanoma (A375) and human breast carcinoma (MDA-MB-231) cell lines under the identical condition with IC 50  value of 149.06 and 124.22 µM, respectively.

Cytotoxic profile study, DNA and protein binding activity of a new dinuclear nickel(II) thiocyanato complex