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The synthesis of five selenium complexes bearing imidazole-based  N -heterocyclic carbene ligands (Se-NHC) are reported. The adducts were characterized by elemental and spectroscopic analysis (FTIR,  1 H and  13 C NMR). Single-crystal XRD confirmed the structures of two Se-NHC adducts,  VIII  and  XI . Zone of inhibition (ZOI) values of Se-NHC complexes were evaluated towards two bacterial ( Bacillus thuringiensis  and  Escherichia coli ) and one fungal strain ( Candida albicans ). The most active tested compound was  XI  with inhibition value of 24.1 ± 0.1 mm against  E. coli , and it showed higher activity than Tetracycline (reference drug). Similarly,  XI  exhibited good inhibition potential against  C. albicans  (26.5 ± 0.2 mm). The hemolytic assay demonstrated that the tested compounds ( VIII - XII ) are non-toxic to healthy human blood; however, thrombolysis indicated that  VIII - XII  could be used as potential thrombolytic agents. It is concluded that Se-NHC carbene adducts having more aromatic rings at terminal nitrogens of imidazole are more effective than other tested compounds. Se-NHC compounds have more efficacy against bacterial strains than fungal strain.

Selenium- N -heterocyclic carbene (Se-NHC) complexes with higher aromaticity inhibit microbes: synthesis, structure, and biological potential