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N,N ′-bis(aniline)glyoxime (H 2 L,  1 ) has been prepared from aniline and ( E,E )-dichloroglyoxime (DCGO) or ( E,E )-dibromoglyoxime (DBGO). The reaction of  N,N′ -bis(aniline)glyoxime (H 2 L,  1 ) with solution of PtCl 2  in dimethylsulfoxide produced brown-colored bis( E,E -dioximato)platinum(II) complex {[( E,E )-Pt(HL) 2 ]} ( 1a ) featuring  N -chelating ligand. The crystal structure of this complex has been identified by X-ray diffraction on a single-crystal.  In vitro  assay of proliferation, cell death, DNA-damage and cell uptake activities of  1  and  1a  were tested in HCC cell lines, SNU-182 and HUH-7.  1a  has an anti-proliferative effect in HCC cells, however,  1  did not. Furthermore, the cellular uptake of  1a  was relatively high compared to cisplatin cellular platinum levels. Compatible with proliferation and cellular uptake results, treatment with  1a  caused DNA-damage and subsequent apoptosis in both HCC cell lines.

Bis[ N,N′ -bis(anilino)glioximato]platinum(II) complex: synthesis, characterization and biological activity