English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background : Thioredoxin-interacting protein (TXNIP) controls the cellular redox balance by binding to and inhibiting the expression and function of thioredoxin. DNA methylation of the  TXNIP  gene is involved in the regulation of TXNIP mRNA expression. Changes in  TXNIP  DNA methylation levels are associated with the development of various diseases such as type 2 diabetes mellitus (T2DM). However, few studies have focused on the influence of lifestyle factors such as alcohol intake on  TXNIP  DNA methylation. Objectives : This research examines the association of drinking behaviors with  TXNIP  DNA methylation levels in the general Japanese population. Methods : We conducted a cross-sectional study of 404 subjects (176 males and 228 females) who were divided into non-, moderate and heavy drinkers based on self-reported drinking behaviors.  TXNIP  DNA methylation levels in leukocytes were determined using a pyrosequencing assay. Results : The mean  TXNIP  DNA methylation level in heavy drinkers (74.2%) was significantly lower than that in non- and moderate drinkers (non: 77.7%,  p  &lt; .001; moderate: 76.6%,  p  = .011). Multivariable linear regression analysis showed that log-transformed values of daily ( b  = −1.34;  p  &lt; .001) and cumulative ( b  = −1.06;  p  = .001) alcohol consumption were associated with decreased  TXNIP  DNA methylation levels. Conclusion :  TXNIP  DNA methylation levels in heavy drinkers was lower than in non- and- moderate drinkers. Decreased  TXNIP  DNA methylation level increases the expression of TXNIP and elevates the risk of developing of diseases such as T2DM. Therefore, decreasing alcohol use in heavy drinkers may lessen the likelihood of some alcohol-related illnesses moderated through  TXNIP  DNA methylation.

Association of drinking behaviors with TXNIP DNA methylation levels in leukocytes among the general Japanese population