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In this study, Gemcitabine (GEM) HCl is loaded in long-circulating polymeric nanoparticles (NPs) using PLGA- PEG-PPG-PEG in combination with succinic anhydride (SA) to overcome issues of rapid metabolism. The optimized batch had size of 230.9 nm, zeta potential of −15.4 mV, and a high entrapment efficiency (EE) of 69.69%. The  in vitro  drug release was sustained up to 72 h. The IC50 values for the MDA-MB-231 cancer cells for free GEM, GP NPs, and GS NPs were 110.47, 91.23, and 78.25 µM. The pharmacokinetic study of the formulated NPs on Sprague Dawley rats confirmed long circulation up to 72 h.

Long circulating polymeric nanoparticles of gemcitabine HCl using PLGA-PEG-PPG-PEG block co-polymer