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Achieving high solubilization capacity with the aid of polymeric micelles (PM) is still a major challenge. To address this shortcoming, novel poly(jasmine lactone) (PJL)-based PM were developed and compared with Soluplus ®  and poly(lactide) copolymer. The presence of “ene” groups on PJL’s backbone offers a unique opportunity to insert functional groups. We introduced -COOH and phenyl groups onto the PJL copolymer and observed a ∼334-fold increment in aqueous solubility of clotrimazole with -COOH-terminated PJL copolymer compared to Soluplus. We thus successfully demonstrated that the presence of appropriate free functional groups on the polymer chain can facilitate the solubilization potential of PM.

international journal of polymeric materials and polymeric biomaterials

Evaluation of solubilizing potential of functional poly(jasmine lactone) micelles for hydrophobic drugs: A comparison with commercially available polymers