English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

This study aims to develop quetiapine (QTP)-loaded  β -cyclodextrin (β-CD) based  co -polymeric thiolated polyethylene glycol-poly(lactic- co -glycolic acid) (t-PEG-PLGA) nanoparticles (QTP@β-CD-t-PEG-PLGA) by transesterification process. As a result, the  ex-vivo  bioadhesion study shows good bioadhesion because of the thiolation of PEG (t-PEG), which can interrelate through mucin and expand the retention time.  In-vitro  release study demonstrates the QTP release to 20 h (∼98.76%). Herein, sulfhydryl ligands can form disulfide bonds with cysteine-rich mucus areas that increased the viscosity of mucin and accordingly drug retention. Hence, it can be significant accomplishment for nose to brain drug targeting in psychotic disorder management.

international journal of polymeric materials and polymeric biomaterials

Development of thiolated polyethylene glycol-poly (lactic-co-glycolic acid) co-polymeric nanoparticles for intranasal delivery of quetiapine:  in vitro – ex vivo  characterization