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A range of D-sorbitol/D-mannitol incorporated  co-polymer s were synthesized via solvent free enzyme catalyzed polycondensation with adipic acid and polyethylene glycol.  In-vitro  cytotoxic studies on breast cancer and fibroblast cell lines showed that the  co-polymer s are biocompatible up to 500 and 250 µg/mL, respectively. However, THP-1 and RAW 264.7 cell lines showed a dose dependent cytotoxicity. Furthermore, these  co -polymers did not produce excessive cytokines (TNFα/IL-6) and chemokines (CXCL-5/CXCL-10) when interacting with THP-1 cells, thereby, not causing any inflammation. Whilst, the expression of IL-1b, CXCL-1 and IFNβ were upregulated. The results suggest that these  co -polymers could be promising vaccine adjuvants.

Immunomodulatory properties of D-sorbitol/D-mannitol incorporated linear step-growth Co -polymers