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Polysulfone (PSF) as an expected potential biomaterial matches well with the urgent demand in biomedical applications on account of outstanding mechanical and chemical compatibility. In this review, the classification of some biological modifiers by the flow mosaic model was described. Then, several distinct modification approaches to PSF were introduced in detail, including blending, surface coating, and grafting. Moreover, diverse biomedical applications (hemodialysis, membrane oxygenator, cartilage scaffold, and so on) and up-to-date explorations were exhaustively presented to provide more information for further researches. Finally, the challenges in biomedical modifications of PSF were summarized and the potential application in biomedicine was forecasted.

Modification of polysulfone and the biomedical application of modified polysulfone