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Due to the poor cell compatibility, capsular contracture is usually accompanied by the implantation of Silicone Rubber (SR). In this study, synthetical carboxyl grafted polyhedral oligomeric silsesquioxane (POSS-COOH) was incorporated into SR to prepare a composite filling material, namely POSS-COOH/SR.  in vivo  implantation showed that the occurrence of capsular formation around POSS-COOH/SR was inhibited,  in vitro  experiment showed cell improved proliferation and adhesion capability on POSS-COOH/SR. Through proteomics analysis, the extracellular matrix (ECM) regulatory protein in the cells on the surface of POSS-COOH/SR changed significantly. In summary, POSS-COOH/SR could be a better biomaterial to scaffold for soft tissue filling.

Novel silicone rubber with carboxyl grafted polyhedral oligomeric silsesquioxane (POSS-COOH) as a potential scaffold for soft tissue filling